Despite the increasing use and the continual progression of the nanoparticle industry, little is known about the potential toxicity of these materials in both humans and the environment. My research focus is on the toxicity of metal/metal oxide nanoparticles in vivo, studying tissue level responses and nanoparticle localisation. Oxidative stress is a major pathway for toxicity to nanoparticles and I will be developing electrophile responsive element (EpRE) green fluorescent protein (GFP) transgenic Zebrafish in order to distinguish which tissues are targeted by this mode of action. I hope to then research the effects of long-term exposure scenarios by using this method in a line of Zebrafish that lacks pigment. These results will be combined with RNA sequencing to define the genetic consequences of nanoparticle exposure. Alongside this, I will be using the Coherent Anti-Stokes Raman Scattering (CARS) technique to determine nanoparticle localisation in the exposed organisms. This research will significantly improve our understanding of nanoparticle toxicity at the whole organism level.
Supervision: Prof. Charles Tyler , Dr. Tetsu Kudoh, Prof Tamara Galloway, Dr Julian Moger
Funding Body: EPSRC
Qualifications
Bsc Biological Sciences (1st class Hons) – University of Exeter
Contact
Lab 201, Biosciences College of Life and Environmental Sciences, Geoffrey Pope, University of Exeter Stocker Road, Exeter, EX4 4QD
Bsc Biological Sciences (1st class Hons) – University of Exeter
Tetsu Kudoh Lab 
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