Dr. Aya Takesono

email: A.Takesono@exeter.ac.uk

I am currently working on functional contributions of oestrogen signalling in brain development using zebrafish. I am also investigating roles of oestrogen receptor isotypes (ER1, ER2a and ER2b) in early phases of zebrafish embryo development, in particular, focusing on their roles in epiboly during gastrulation.


1990-1994, Tokyo University of Pharmacy and Life Sciences, Japan, BS and pharmacist

1994-1996, University of Tokyo, Japan, M.Sci.

1996-1999, University of Tokyo, Japan, Ph.D.

1996-1998, Medical University of South Carolina, SC, USA, Visiting Ph.D. student


2000-2003, National Human Genome Research Institute, Natinal Institute of Health, MD, USA, Postdoctoral Fellow

2003-2006, Ludwig Institute for Cancer Research, UCL, London, UK, Postdoctoral Fellow

2007, School of Biosciences, University of Exeter, Royal Society Research Fellow

2008-present, College of Life and Environmental Sciences, Biosciences, University of Exeter, UK, Postdoctoral Fellow


Journal articles

1)Biosensor Zebrafish Provide New Insights into Potential Health Effects of Environmental Estrogens.

Lee O, Takesono A, Tada M, Tyler CR, Kudoh T.

Environ Health Perspect. 2012 Mar 30.

2) Slc3a2 controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo

Takesono A, Moger J, Faroq S, Cartwright E, Dawid IB, Wilson SW, and Kudoh T.

PNAS. 2012Feb 28;109(9):3371-6.

3) Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells.

Takesono A, Heasman SJ, Wojciak-Stothard B, Garg R, Ridley AJ.

PLoS One. 2010 Jan 19;5(1):e8774.

 4) T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.

David R, Ma L, Ivetic A, Takesono A, Ridley AJ, Chai JG, Tybulewicz VL, Marelli-Berg FM.

Blood. 2009 Apr 16;113(16):3696-705.

5) T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.

Jarmin SJ, David R, Ma L, Chai JG, Dewchand H, Takesono A, Ridley AJ, Okkenhaug K, Marelli-Berg FM.

J Clin Invest. 2008 Mar;118(3):1154-64.

6) Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

Dombroski D, Houghtling RA, Labno CM, Precht P, Takesono A, Caplen NJ, Billadeau DD, Wange RL, Burkhardt JK, Schwartzberg PL.

J Immunol. 2005 Feb 1;174(3):1385-92.

7) Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac.

Takesono A, Horai R, Mandai M, Dombroski D, Schwartzberg PL.

Curr Biol. 2004 May 25;14(10):917-22.

8) Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free media.

Cheng J, Dutra A, Takesono A, Garrett-Beal L, Schwartzberg PL.

Genesis. 2004 Jun;39(2):100-4.

9) Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

Labno CM, Lewis CM, You D, Leung DW, Takesono A, Kamberos N, Seth A, Finkelstein LD, Rosen MK, Schwartzberg PL, Burkhardt JK.

Curr Biol. 2003 Sep 16;13(18):1619-24.

10) Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator.

Ribas C, Takesono A, Sato M, Hildebrandt JD, Lanier SM.

J Biol Chem. 2002 Dec 27;277(52):50223-5. Epub 2002 Nov 7.

11) Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes.

Takesono A, Nowak MW, Cismowski M, Duzic E, Lanier SM.

J Biol Chem. 2002 Apr 19;277(16):13827-30. Epub 2002 Feb 12.

12) Identification of modulators of mammalian G-protein signaling by functional screens in the yeast Saccharomyces cerevisiae.

Cismowski MJ, Takesono A, Ma C, Lanier SM, Duzic E.

Methods Enzymol. 2002;344:153-68.

13) Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains.

Pizzinat N, Takesono A, Lanier SM.

J Biol Chem. 2001 May 18;276(20):16601-10. Epub 2001 Feb 5.

14) Receptor-independent activators of heterotrimeric G-protein signaling pathways.

Takesono A, Cismowski MJ, Ribas C, Bernard M, Chung P, Hazard S 3rd, Duzic E, Lanier SM.

J Biol Chem. 1999 Nov 19;274(47):33202-5.

15) Negative regulation of alpha2-adrenergic receptor-mediated Gi signalling by a novel pathway.

Takesono A, Zahner J, Blumer KJ, Nagao T, Kurose H.

Biochem J. 1999 Oct 1;343 Pt 1:77-85.

16) Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.

Cismowski MJ, Takesono A, Ma C, Lizano JS, Xie X, Fuernkranz H, Lanier SM, Duzic E.

Nature Biotechnol. 1999 Sep;17(9):878-83.


1) Beyond calcium: new signaling pathways for Tec family kinases.

Takesono A, Finkelstein LD, Schwartzberg PL.

J Cell Sci. 2002 Aug 1;115(Pt 15):3039-48. Review.

2) Receptor-independent activators of heterotrimeric G-proteins.

Cismowski MJ, Takesono A, Bernard ML, Duzic E, Lanier SM.

Life Sci. 2001 Apr 6;68(19-20):2301-8. Review.