My research aims to further develop the highly novel transgenic zebrafish (ERE-TG) model previously developed by our group. Currently, I have established the same fluorescence response to oestrogenic chemicals in a pigment free strain of zebrafish (ERE-TG Casper). This model will allow us to investigate the effects of oestrogenic chemical mixtures on tissue responses throughout development and adult stages. I am working towards the generation of a similar transparent model using a fluorescent protein that changes colour upon exposure to UV-light (Kaede protein). This model will allow us to monitor tissue response to sequential estrogenic exposures throughout all stages of development.
I am also looking to establish these transgenic zebrafish models in a multi-well system for a high-throughput screening system for oestrogenic chemicals. This project is in collaboration with AstraZeneca.
Funding Bodies: BBSRC and AstraZeneca
Supervision: Prof. Charles Tyler (UoE), Dr. Tetsu Kudoh (UoE) & Ross Brown (AstraZeneca)
BSc Biochemistry with One Year of Industrial Work Experience, University of Birmingham. Industrial placement at AstraZeneca, R&D Safety Assessment, Alderley Park
Lab 201, Biosciences College of Life and Environmental Sciences, Geoffrey Pope, University of Exeter Stocker Road, Exeter, EX4 4QD
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