Olivia Osborne

email: ojo201@ex.ac.uk

Current Research

My research is looking into the ecotoxicology of nanoparticles and their potential effects in fish. My main focus to date has been to investigate the uptake and effects of metal oxides nanoparticles in zebrafish. In this work I have been applying whole mount in-situ hybridization in zebrafish embryos as an integrative approach for identifying gene target and tissues for metal/metal oxide particles. In my studies I have applied a series of other assays including acute toxicity tests, assays for apoptosis, and morphological assessments to investigate nanomaterial toxicity. I have also used Coherent Anti Raman Scattering as an imaging technique to localize the nanomaterials in the exposed organisms.

Funding Body: NERC and Environmental Agency

Presentations

  • Research Day June 2010 at the Peninsula College of Medicine and Dentistry
    Poster Presentation: Investigating the Biological effects of Engineered Nanoparticles in a Fish Model
  • Microscopy & Analysis Conference January 2011 at the University of Bath
    Poster Presentation: Investigating the Biological effects of Engineered Nanoparticles in a Fish Model
  • 6th International Conference on the Environmental Effects of Nanoparticles and Nanomaterials at the Royal Society, London September 2011
    Oral Presentation:  Effects of particle size and coating on nanoscale Ag and TiO2 exposure in zebrafish embryos (Danio rerio)
  • 7th International Conference on the Environmental Effects of Nanoparticles and Nanomaterials ,The Banff Centre, Banff, AB Canada, September 2012
    Poster Presentation: Application of in situ hybridization in zebrafish to identify target tissues and effect mechanisms of a metal based nanoparticle (silver)
  • 8th International Conference on the Environmental Effects of Nanoparticles and Nanomaterials ,Aix en Provence, France, July 2013
    Poster Presentation: Application of in situ hybridization in zebrafish to identify target tissues and effect mechanisms of a metal based nanoparticle (silver)
  • 8th European Zebrafish Conference, Barcelona, July 2013
    Oral Presentation: Application of in situ hybridization in zebrafish to identify target tissues and effect mechanisms of a metal based nanoparticle (silver)

Publications

Osborne, O.J., Johnston, B., Moger, J., Baalousha, M., Lead, J., Kudoh, T., Tyler, C. “Effects of particle size and coating on nanoscale Ag and TiO2 exposure in zebrafish (Danio rerio) embryos”(2012) Nanotoxicology  doi:10.3109/17435390.2012.737484

Qualifications

BSc (Exon) (Hons) Biological Sciences

Contact

Telephone: 01392724677

Building/Room number: Biosciences, College of Life and Environmental Sciences University of Exeter Lab 201 Geoffrey Pope Building Stocker Road Exeter Devon EX4 4QD